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pentobarbital will lessen the extent or result of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.lasmiditan, pentobarbital. Possibly boosts effects of the opposite by sedation. Use Caution/Watch. Coadministration of lasmiditan along with other CNS depressant drugs, including Alcoholic be